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(Solved): Human immunodeficiency virus 1 (HIV-1) protease inhibitors have been successful at lowering HIV-1 l ...




Human immunodeficiency virus 1 (HIV-1) protease inhibitors have been successful at lowering HIV-1 levels anilj blocking the o
Compound 1 has been shown to inhibit HIV-1 protease with \( K_{i}=60.3 \mu \mathrm{M} \) (Table 1). \( K_{1} \) is the dissoc
What quantity of Compound \( \mathbf{1} \) must be provided to prepare \( 100.00 \mathrm{~mL} \) of solution with a concentra
Human immunodeficiency virus 1 (HIV-1) protease inhibitors have been successful at lowering HIV-1 levels anilj blocking the onset of acquired immune deficiency syndrome (AIDS). However, because HIV-1 mutants are developing resistance to current protease inhibitors, new inhibitors such as Compound 1 (molar mass: \( 483.5 \mathrm{~g} \mathrm{~mol}^{-1} \) ) are being tested. Compound 1 Compound 1 has been shown to inhibit HIV-1 protease with \( K_{1}=60.3 \mu \mathrm{M} \) (Table 1). \( K_{i} \) is the dissociation constant for the enzyme-bound inhibitor, which is either EI or ESI, depending on the type of inhibitor. The peptide substrate for HIV-1 protease is IRKILFLDG. HIV-1 protease hydrolyzes only the peptide bond after leucine and before phenylalanine. Compound 1 has been shown to inhibit HIV-1 protease with \( K_{i}=60.3 \mu \mathrm{M} \) (Table 1). \( K_{1} \) is the dissociation constant for the enzyme-bound inhibitor, which is either EI or ESI, depending on the type of inhibitor. The peptide substrate for HIV-1 protease is IRKILFI.DG. HIV-1 protease hydrolyzes only the peptide bond after leucine and before phenylalanine. Table 1 Kinetic Parameters of HIV-1 Protease with and without Compound 1 Note: HIV-1 protease tollows Michaelis-Menten kinetics. A Lineweaver-Burk plot of \( V_{0}{ }^{-1} \) versus \( [\mathrm{S}]^{-1} \), both without Compound 1 and with different concentrations of Compound 1 , generates a set of parallel straight lines with positive slopes. What quantity of Compound \( \mathbf{1} \) must be provided to prepare \( 100.00 \mathrm{~mL} \) of solution with a concentration equal to \( K \) ? A. \( 48.4 \mathrm{mg} \) B. \( 24.2 \mathrm{mg} \) C. \( 5.64 \mathrm{mg} \) D. \( 2.92 \mathrm{mg} \)


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